The New-Generation Muscle Relaxant MPH-220 Dissolves Spasticity in Muscles After Cns Injury - a Promising Drug to Address Post-Stroke Spasticity
نویسندگان
چکیده
منابع مشابه
New insights into the pathophysiology of post-stroke spasticity
Spasticity is one of many consequences after stroke. It is characterized by a velocity-dependent increase in resistance during passive stretch, resulting from hyperexcitability of the stretch reflex. The underlying mechanism of the hyperexcitable stretch reflex, however, remains poorly understood. Accumulated experimental evidence has supported supraspinal origins of spasticity, likely from an ...
متن کاملPredictors of Spasticity After Stroke
PURPOSE OF REVIEW Spasticity is a part of the upper motor neuron syndrome and can result in reduced function. Reduction of the complications may be facilitated by early intervention, making identification of stroke patients at high risk for developing spasticity essential. RECENT FINDING Different predictors of poststroke spasticity (PSS) have been suggested in different studies, including de...
متن کاملBiomechanical measurement of post-stroke spasticity.
BACKGROUND spasticity following stroke is common, but clinical measurement is difficult and inaccurate. The most common measure is the modified Ashworth scale (MAS) which grades resistance to passive movement (RPM), but its validity is unclear. AIM to assess the validity of the MAS. METHODS spasticity was clinically graded using MAS and RPM measured biomechanically in the impaired arm of 11...
متن کاملSpasticity and muscle contracture following stroke.
It has become increasingly recognized that the major functional deficits following brain damage are largely due to "negative' features such as weakness and loss of dexterity rather than spasticity. A variety of studies suggest that spasticity is a distinct problem and separate from the loss of dexterity, but that it may be implicated in the formation of muscle contracture and even in the recove...
متن کاملDoes Spasticity Interfere with Functional Recovery after Stroke? a Novel Approach to Understand, Measure and Treat Spasticity after Acute Stroke
Objective: To explore, following a literature review, if there was a consistent definition and a unified assessment framework for the term ‘spasticity’. The congruence between the definitions of spasticity and the corresponding methods of measurement were also explored. Data sources: The search was performed on the electronic databases of Web of Science, Science Direct and Medline. Review metho...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.2438